While the letter X does not explicitly appear in biblical texts, its form as a cross or mark resonates with several scriptural motifs. In Ezekiel 9:4, a mark is placed on the foreheads of the righteous as a sign of divine protection, prefiguring the idea of being set apart. The Passover narrative (Exodus 12) also employs a marked threshold as a symbol of salvation and exclusion from judgment. The X, as an intersection, can further evoke the crossing of destinies or the convergence of divine plans, echoing the motif of crossroads in biblical journeys and decisions.

Although the letter X is not a traditional Buddhist symbol, the act of crossing out or marking can represent the cessation of attachment (nirodha) and the deliberate rejection of ignorance (avidya). An X may symbolize the mindful turning away from unwholesome actions (akusala) and the intersection of samsara and nirvana, highlighting the practitioner's choice of the Middle Way. It can also denote the extinguishing of desires that bind one to suffering.

Culturally, X is a universal symbol for negation, prohibition, and error. It marks choices, denotes hidden treasure ('X marks the spot'), and signals danger or taboo. In modern contexts, X can represent anonymity, mystery, or the unknown, as in 'Generation X' or 'Project X.' Its use in signatures (e.g., signing with an X) can imply secrecy, affection, or a lack of identity, depending on context.

Hindu symbolism often employs marks (tilaka, bindu) for spiritual protection and status. An X, as a crossing, might represent the union of Shiva and Shakti, the intersection of material and spiritual realms, or the convergence of karmic cycles. It can signify the closing of one phase and the opening of another, marking pivotal transitions on the path of dharma and spiritual evolution.

Though the Arabic script lacks the letter X, the concept of marking or crossing out is present in Islamic tradition. The Qur’an references distinguishing marks (ayat) that separate the righteous from wrongdoers (Qur’an 7:46). An X-like symbol may represent prohibition (haram), a boundary between truth and falsehood, or the act of erasing sins through repentance (tawbah). In dreams, such a mark could signal the need to avoid forbidden actions or to seek spiritual purification.

Psychologically, X is a potent archetype of negation, boundaries, and decision points. Jungian analysis sees such symbols as emerging from the unconscious to signify repression, denial, or the need to confront shadow elements. An X can indicate a psychological barrier, a crossroads requiring choice, or the desire to erase unwanted aspects of the self. It may also represent the intersection of conflicting drives or the marking of a transformative threshold.

Spiritually, X is a symbol of intersection, transformation, and protection. It marks the meeting of opposites—light and dark, conscious and unconscious—and signals a moment of awakening or decision. In esoteric traditions, the X can serve as a protective seal or as a reminder to examine hidden aspects of the self. It may also signify a spiritual crossroads, where choices lead to growth or stagnation.